Opioid-Induced Constipation #1

Which of the following treatments is ineffective in treating opioid-induced constipation?

a. Senna
b. Docusate sodium
c. Manual evacuation
d. Polyethylene glycol

The correct answer: B.

In randomized controlled studies for opioid-induced constipation, the use of docusate sodium did not result in improved laxation when compared to placebo. Senna (stimulant laxative) and polyethylene glycol (osmotic laxative) are both cornerstones of treatment for opioid-induced constipation. Manual dis-impaction may be required if hardened stool is retained in the rectal vault.

FAST FACTS AND CONCEPTS #294. Opioid induced constipation